Neurometabolic Network (NMetNet) for Functional Neurological Disorder in Children and Adolescents
Lan Z., Foster S., Charney M., van Grinsven M., Breedlove K., Kozlowska K., Lin A.
NeuroImage: Clinical (2025)
- Clinical Study, Research Translation
Key Takeaways
- Changes in energy management and oxidative balance impact kids with Functional Neurological Disorder (FND).
- Loss of certain neurometabolite connections (like creatine and glutathione) is linked with FND symptoms.
- These changes are more intense for those with functional seizures.
- Understanding brain chemical connections opens new paths for treating FND.
- More research could explore how exercise and diet might improve FND symptoms.
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Overview
This summary looks at changes in brain chemicals for kids with FND. The study aimed to identify differences in how brain regions interact in FND, focusing on connections between specific chemicals known as neurometabolites.
Discussion
The research involved comparing 32 kids with FND and 41 healthy kids using advanced imaging to study brain chemicals.
Methods:
- Evaluated six neurometabolites in brain areas.
- Used brain scans to view how connections differ in FND.
Findings:
- FND kids showed differences in chemicals crucial for energy and antioxidant protection in the brain.
- Key connections differ, especially for those with functional seizures.
Implications:
- These insights suggest potential treatments targeting brain chemistry.
- Limitations include the small number of participants, suggesting further studies are needed.
Next Steps
If you have FND, here are some steps you can consider:
- Explore regular moderate exercise and a balanced diet to support brain health.
- Discuss new insights from this study with your healthcare provider.
- Track symptoms and check if treatments are helping.
- Connect with FND communities for shared experiences and support.
- Stay hopeful; ongoing research may lead to new treatment options.
Reference
Lan Z., Foster S., Charney M., van Grinsven M., Breedlove K., Kozlowska K., Lin A. Neurometabolic network (NMetNet) for functional neurological disorder in children and adolescents. NeuroImage: Clinical. 2025;46:103767. doi:[10.1016/j.nicl.2025.103767]
This summary is provided for informational purposes only and does not constitute medical, financial, or legal advice. It is not intended to replace professional consultation or treatment. Always consult qualified healthcare providers regarding your specific circumstances, symptoms, or questions.